|Other Names||Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Nek8, Jck|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13927b was selected from the C-term region of Mouse Nek8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells|
|Tissue Location||Kidney, liver, and testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a NIMA-related kinase. Members of thisserine/threonine protein kinase family are structurally-related toNIMA (never in mitosis, gene A) which controls mitotic signaling inAspergillus nidulans.
Hellman, N.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107(43):18499-18504(2010)Ahmadie, R., et al. J. Nutr. 140(8):1438-1444(2010)Natoli, T.A., et al. Nat. Med. 16(7):788-792(2010)Shiba, D., et al. Cytoskeleton (Hoboken) 67(2):112-119(2010)Sohara, E., et al. J. Am. Soc. Nephrol. 19(3):469-476(2008)
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