|Other Names||Serine/threonine-protein kinase PAK 3, Beta-PAK, CDC42/RAC effector kinase PAK-B, p21-activated kinase 3, PAK-3, Pak3, Pak-3, Pakb, Stk4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13931a was selected from the N-term region of Mouse Pak3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Pak-3, Pakb, Stk4|
|Function||Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.|
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Key regulator of synapse formation and plasticity in the hippocampus.
Shimogori, T., et al. Nat. Neurosci. 13(6):767-775(2010)Jiang, X.S., et al. Hum. Mol. Genet. 19(7):1347-1357(2010)Demyanenko, G.P., et al. Neuroscience 165(1):107-115(2010)Grimsley-Myers, C.M., et al. J. Neurosci. 29(50):15859-15869(2009)Sansom, S.N., et al. PLoS Genet. 5 (6), E1000511 (2009) :
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