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DGCR14 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96DF8
Clone Names 90429101
Additional Information
Gene ID 8220
Other Names Protein DGCR14, DiGeorge syndrome critical region 13, DiGeorge syndrome critical region 14, DiGeorge syndrome protein H, DGS-H, Protein ES2, DGCR14, DGCR13, DGSH, DGSI, ES2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13938c was selected from the Center region of DGCR14. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESS2 (HGNC:16817)
Function May be involved in pre-mRNA splicing.
Cellular Location Nucleus {ECO:0000250|UniProtKB:P34420}.
Tissue Location Highly expressed in heart, brain and skeletal muscle. Detected at low levels in placenta
Research Areas
Citations (0)
citation

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Background

This gene is located within the minimal DGS criticalregion (MDGCR) thought to contain the gene(s) responsible for agroup of developmental disorders. These disorders include DiGeorgesyndrome, velocardiofacial syndrome, conotruncal anomaly facesyndrome, and some familial or sporadic conotruncal cardiac defectswhich have been associated with microdeletion of 22q11.2. Theencoded protein may be a component of C complex spliceosomes, andthe orthologous protein in the mouse localizes to the nucleus.

References

Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Wang, H., et al. J Neural Transm 113(10):1551-1561(2006)Jurica, M.S., et al. RNA 8(4):426-439(2002)

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$ 277.78
Cat# BP13938c
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Availability: 2 weeks
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