|Other Names||Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13939c was selected from the Center region of DPYSL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes|
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Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. DPYSL2 plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)Koide, T., et al. J. Hum. Genet. 55(7):469-472(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chae, Y.C., et al. Cell. Signal. 21(12):1818-1826(2009)Arimura, N., et al. J. Neurochem. 111(2):380-390(2009)
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