|Other Names||Amiloride-sensitive amine oxidase [copper-containing], DAO, Diamine oxidase, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, KAO, AOC1, ABP1, DAO1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13940a was selected from the N-term region of ABP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Placenta and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a membrane glycoprotein that isexpressed in many epithelium-rich and/or hematopoietic tissues andoxidatively deaminates putrescine and histamine. The protein mayplay a role in controlling the level of histamine and/or putrescinein these tissues. It also binds to and is inhibited by amiloride, adiuretic that acts by closing epithelial sodium ion channels.
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)McGrath, A.P., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 2), 137-142 (2010) :Chambers, J.C., et al. Nat. Genet. 42(2):149-152(2010)McGrath, A.P., et al. Biochemistry 48(41):9810-9822(2009)Song, W.B., et al. World J. Gastroenterol. 15(31):3916-3919(2009)
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