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ABP1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P19801
Clone Names 90429002
Additional Information
Gene ID 26
Other Names Amiloride-sensitive amine oxidase [copper-containing], DAO, Diamine oxidase, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, KAO, AOC1, ABP1, DAO1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13940a was selected from the N-term region of ABP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AOC1
Synonyms ABP1, DAO1
Function Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Cellular Location Secreted, extracellular space.
Tissue Location Placenta and kidney.
Research Areas
Citations (0)
citation

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Background

This gene encodes a membrane glycoprotein that isexpressed in many epithelium-rich and/or hematopoietic tissues andoxidatively deaminates putrescine and histamine. The protein mayplay a role in controlling the level of histamine and/or putrescinein these tissues. It also binds to and is inhibited by amiloride, adiuretic that acts by closing epithelial sodium ion channels.

References

Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)McGrath, A.P., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 2), 137-142 (2010) :Chambers, J.C., et al. Nat. Genet. 42(2):149-152(2010)McGrath, A.P., et al. Biochemistry 48(41):9810-9822(2009)Song, W.B., et al. World J. Gastroenterol. 15(31):3916-3919(2009)

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$ 277.78
Cat# BP13940a
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Availability: 2 weeks
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