|Other Names||Cytokine-dependent hematopoietic cell linker, Mast cell immunoreceptor signal transducer, CLNK, MIST|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13943c was selected from the Center region of MIST. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
MIST is a member of the SLP76 family of adaptors (seeLCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in theregulation of immunoreceptor signaling, including PLC-gamma (PLCG1;MIM 172420)-mediated B cell antigen receptor (BCR) signaling andFC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast celldegranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al.,2000, 2001 [PubMed 10744659] [PubMed 11463797]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)Goitsuka, R., et al. J. Biol. Chem. 276(38):36043-36050(2001)Goitsuka, R., et al. Int. Immunol. 12(4):573-580(2000)Cao, M.Y., et al. J. Exp. Med. 190(10):1527-1534(1999)
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