|Other Names||Solute carrier family 22 member 1, Organic cation transporter 1, hOCT1, SLC22A1, OCT1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13944b was selected from the C-term region of SLC22A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines|
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Polyspecific organic cation transporters in the liver,kidney, intestine, and other organs are critical for elimination ofmany endogenous small organic cations as well as a wide array ofdrugs and environmental toxins. This gene is one of three similarcation transporter genes located in a cluster on chromosome 6. Theencoded protein contains twelve putative transmembrane domains andis a plasma integral membrane protein. Two transcript variantsencoding two different isoforms have been found for this gene, butonly the longer variant encodes a functional transporter. [providedby RefSeq].
Takahashi, N., et al. J. Hum. Genet. 55(11):731-737(2010)Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Gambineri, A., et al. J. Clin. Endocrinol. Metab. 95 (10), E204-E208 (2010) :Becker, M.L., et al. Neurogenetics (2010) In press :
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