|Other Names||TNF receptor-associated factor 3, 632-, CAP-1, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, LMP1-associated protein 1, LAP1, TRAF3, CAP1, CRAF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13945b was selected from the C-term region of TRAF3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.|
|Cellular Location||Cytoplasm. Endosome. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the TNFreceptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from, membersof the TNF receptor (TNFR) superfamily. This protein participatesin the signal transduction of CD40, a TNFR family member importantfor the activation of the immune response. This protein is found tobe a critical component of the lymphotoxin-beta receptor (LTbetaR)signaling complex, which induces NF-kappaB activation and celldeath initiated by LTbeta ligation. Epstein-Barr virus encodedlatent infection membrane protein-1 (LMP1) can interact with thisand several other members of the TRAF family, which may beessential for the oncogenic effects of LMP1. Three alternativelyspliced transcript variants encoding two distinct isoforms havebeen reported.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Song, Y.J., et al. Virus Genes 41(2):174-180(2010)Perez de Diego, R., et al. Immunity 33(3):400-411(2010)del Rio-Espinola, A., et al. Pharmacogenomics 11(6):763-772(2010)Sanjo, H., et al. J. Biol. Chem. 285(22):17148-17155(2010)
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