|Other Names||TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13946a was selected from the N-term region of TRAF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.|
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The protein encoded by this gene is a member of the TNFreceptor (TNFR) associated factor (TRAF) protein family. TRAFproteins associate with, and mediate the signal transduction fromvarious receptors of the TNFR superfamily. This protein and TRAF2form a heterodimeric complex, which is required forTNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. Theprotein complex formed by this protein and TRAF2 also interactswith inhibitor-of-apoptosis proteins (IAPs), and thus mediates theanti-apoptotic signals from TNF receptors. The expression of thisprotein can be induced by Epstein-Barr virus (EBV). EBV infectionmembrane protein 1 (LMP1) is found to interact with this and otherTRAF proteins; this interaction is thought to link LMP1-mediated Blymphocyte transformation to the signal transduction from TNFRfamily receptors. Three transcript variants encoding two differentisoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)Tan, R.J., et al. Ann. Rheum. Dis. 69(6):1029-1035(2010)Vuong, M.T., et al. PLoS ONE 5 (5), E10559 (2010) :
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