|Other Names||Translin-associated protein X, Translin-associated factor X, TSNAX, TRAX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13947a was selected from the N-term region of TSNAX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.|
|Cellular Location||Cytoplasm, perinuclear region. Golgi apparatus. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity) Expressed in the cytoplasm in the presence of TSN.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which specifically interactswith translin, a DNA-binding protein that binds consensus sequencesat breakpoint junctions of chromosomal translocations. The encodedprotein contains bipartite nuclear targeting sequences that mayprovide nuclear transport for translin, which lacks any nucleartargeting motifs.
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Schosser, A., et al. Mol. Psychiatry 15(8):844-849(2010)Okuda, A., et al. Neuromolecular Med. 12(1):78-85(2010)Nakata, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15873-15878(2009)Palo, O.M., et al. Hum. Mol. Genet. 16(20):2517-2528(2007)
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