|Other Names||Protein Wnt-8b, WNT8B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13948b was selected from the C-term region of WNT8B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expression is restricted to the brain, and more specifically to the forebrain.|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 95%, 86% and 71% amino acid identityto the mouse, zebrafish and Xenopus Wnt8B proteins, respectively.The expression patterns of the human and mouse genes appearidentical and are restricted to the developing brain. Thechromosomal location of this gene to 10q24 suggests it as acandidate gene for partial epilepsy.
Katoh, M., et al. Int. J. Oncol. 30(5):1273-1277(2007)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Deloukas, P., et al. Nature 429(6990):375-381(2004)Saitoh, T., et al. Int. J. Oncol. 20(5):999-1003(2002)Saitoh, T., et al. Int. J. Oncol. 20(2):343-348(2002)
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