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UGT1A1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P22309
Clone Names 90723130
Peptide ID 90723130
Additional Information
Gene ID 54658
Other Names UDP-glucuronosyltransferase 1-1, UDPGT 1-1, UGT1*1, UGT1-01, UGT11, Bilirubin-specific UDPGT isozyme 1, hUG-BR1, UDP-glucuronosyltransferase 1-A, UGT-1A, UGT1A, UDP-glucuronosyltransferase 1A1, UGT1A1, GNT1, UGT1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13949a was selected from the N-term region of UGT1A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UGT1A1
Synonyms GNT1, UGT1
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Cellular Location Isoform 1: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin.
Research Areas
Citations (0)

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This gene encodes a UDP-glucuronosyltransferase, an enzymeof the glucuronidation pathway that transforms small lipophilicmolecules, such as steroids, bilirubin, hormones, and drugs, intowater-soluble, excretable metabolites. This gene is part of acomplex locus that encodes several UDP-glucuronosyltransferases.The locus includes thirteen unique alternate first exons followedby four common exons. Four of the alternate first exons areconsidered pseudogenes. Each of the remaining nine 5' exons may bespliced to the four common exons, resulting in nine proteins withdifferent N-termini and identical C-termini. Each first exonencodes the substrate binding site, and is regulated by its ownpromoter. The preferred substrate of this enzyme is bilirubin,although it also has moderate activity with simple phenols,flavones, and C18 steroids. Mutations in this gene result inCrigler-Najjar syndromes types I and II and in Gilbert syndrome.


Italia, K.Y., et al. Clin. Biochem. 43 (16-17), 1329-1332 (2010) :Justenhoven, C., et al. Breast Cancer Res. Treat. 124(1):289-292(2010)Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Sai, K., et al. Br J Clin Pharmacol 70(2):222-233(2010)Kilic, I., et al. Int J Clin Pharmacol Ther 48(8):504-508(2010)

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$ 80.00
Cat# BP13949a
Availability: In Stock
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