|Other Names||Suppressor of SWI4 1 homolog, Ssf-1, Brix domain-containing protein 3, Peter Pan homolog, PPAN, BXDC3, SSF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13950b was selected from the C-term region of PPAN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in cell growth.|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Widely expressed.|
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The protein encoded by this gene is an evolutionarilyconserved protein similar to yeast SSF1 as well as to the geneproduct of the Drosophila gene peter pan (ppan). SSF1 is known tobe involved in the second step of mRNA splicing. Both SSF1 and ppanare essential for cell growth and proliferation. Exogenousexpression of this gene was reported to reduce theanchorage-independent growth of some tumor cells. Read-throughtranscription of this gene with P2RY11/P2Y(11), an adjacentdownstream gene that encodes an ATP receptor, has been found. Theseread-through transcripts are ubiquitously present and up-regulatedduring granulocyte differentiation.
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Duhant, X., et al. J. Immunol. 169(1):15-21(2002)
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