|Other Names||Carbohydrate sulfotransferase 14, Dermatan 4-sulfotransferase 1, D4ST-1, hD4ST1, CHST14, D4ST1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13951c was selected from the Center region of CHST14. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the HNK-1 family ofsulfotransferases. The encoded protein transfers sulfate to the C-4hydroxyl of N-acetylgalactosamine residues in dermatan sulfate.Mutations in this gene have been associated with adductedthumb-clubfoot syndrome.
Miyake, N., et al. Hum. Mutat. 31(8):966-974(2010)Dundar, M., et al. Am. J. Hum. Genet. 85(6):873-882(2009)Pacheco, B., et al. Glycobiology 19(11):1197-1203(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Mikami, T., et al. J. Biol. Chem. 278(38):36115-36127(2003)
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