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CHST14 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NCH0
Clone Names 90904079
Additional Information
Gene ID 113189
Other Names Carbohydrate sulfotransferase 14, Dermatan 4-sulfotransferase 1, D4ST-1, hD4ST1, CHST14, D4ST1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13951c was selected from the Center region of CHST14. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHST14
Synonyms D4ST1
Function Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Cellular Location Golgi apparatus membrane; Single- pass type II membrane protein
Tissue Location Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid
Research Areas
Citations (0)
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Background

This gene encodes a member of the HNK-1 family ofsulfotransferases. The encoded protein transfers sulfate to the C-4hydroxyl of N-acetylgalactosamine residues in dermatan sulfate.Mutations in this gene have been associated with adductedthumb-clubfoot syndrome.

References

Miyake, N., et al. Hum. Mutat. 31(8):966-974(2010)Dundar, M., et al. Am. J. Hum. Genet. 85(6):873-882(2009)Pacheco, B., et al. Glycobiology 19(11):1197-1203(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Mikami, T., et al. J. Biol. Chem. 278(38):36115-36127(2003)

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$ 277.78
Cat# BP13951c
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