VASH2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86V25 |
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Clone Names | 91216051 |
Gene ID | 79805 |
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Other Names | Vasohibin-2, Vasohibin-like protein, VASH2, VASHL |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13956b was selected from the C-term region of VASH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | VASH2 (HGNC:25723) |
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Synonyms | VASHL |
Function | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). |
Cellular Location | Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). Associates with microtubules (PubMed:31235911) |
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Provided below are standard protocols that you may find useful for product applications.
Background
VASH2 is a angiogenesis inhibitor. It inhibits network formation by endothelial cells.
References
Kimura, H., et al. Blood 113(19):4810-4818(2009)Shibuya, T., et al. Arterioscler. Thromb. Vasc. Biol. 26(5):1051-1057(2006)
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