SELI Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9C0D9 |
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Clone Names | 91113155 |
Gene ID | 85465 |
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Other Names | Ethanolaminephosphotransferase 1, hEPT1, Selenoprotein I, SelI, EPT1, KIAA1724, SELI |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13958a was selected from the N-term region of SELI. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SELENOI (HGNC:29361) |
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Function | Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway (PubMed:17132865, PubMed:28052917, PubMed:29500230). PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes (PubMed:17132865). The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment (PubMed:29500230). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a selenoprotein, which contains aselenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translationtermination. The 3' UTR of selenoprotein genes have a commonstem-loop structure, the sec insertion sequence (SECIS), that isnecessary for the recognition of UGA as a Sec codon rather than asa stop signal.
References
Ugochukwu, C.C., et al. Int J Lab Hematol 30(4):312-316(2008)Horibata, Y., et al. J. Lipid Res. 48(3):503-508(2007)Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)
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