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Synthetic peptide
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- BACKGROUND
| Primary Accession | Q9ULR5 |
|---|---|
| Clone Names | 91218233 |
| Peptide ID | 91218233 |
| Gene ID | 400961 |
|---|---|
| Other Names | Polyadenylate-binding protein-interacting protein 2B, PABP-interacting protein 2B, PAIP-2B, Poly(A)-binding protein-interacting protein 2B, PAIP2B, KIAA1155 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13963b was selected from the C-term region of PAIP2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PAIP2B |
|---|---|
| Synonyms | KIAA1155 |
| Function | Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. |
| Tissue Location | Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Most mRNAs, except for histones, contain a 3-prime poly(A)tail. Poly(A)-binding protein (PABP; see MIM 604679) enhancestranslation by circularizing mRNA through its interaction with thetranslation initiation factor EIF4G1 (MIM 600495) and the poly(A)tail. Various PABP-binding proteins regulate PABP activity,including PAIP1 (MIM 605184), a translational stimulator, andPAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry etal., 2006 [PubMed 17381337]).
References
Berlanga, J.J., et al. RNA 12(8):1556-1568(2006)Derry, M.C., et al. Cold Spring Harb. Symp. Quant. Biol. 71, 537-543 (2006) :
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