|Other Names||Cystatin-SA, Cystatin-2, Cystatin-S5, CST2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13967a was selected from the N-term region of CST2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease inhibitor.|
|Tissue Location||Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland|
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Provided below are standard protocols that you may find useful for product applications.
The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions, where they appear toprovide protective functions. The cystatin locus on chromosome 20contains the majority of the type 2 cystatin genes and pseudogenes.This gene is located in the cystatin locus and encodes a secretedthiol protease inhibitor found at high levels in saliva, tears andseminal plasma.
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Liu, C., et al. Mol. Med. 14 (9-10), 575-581 (2008) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Ito, T., et al. Mol. Immunol. 42(10):1259-1263(2005)
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