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NOX5 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96PH1 |
|---|---|
| Clone Names | 100318060 |
| Gene ID | 79400 |
|---|---|
| Other Names | NADPH oxidase 5, 163-, NOX5 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13968b was selected from the C-term region of NOX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NOX5 |
|---|---|
| Function | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). |
| Cellular Location | [Isoform v2]: Endoplasmic reticulum. Cell membrane; Multi-pass membrane protein. Note=Calcium-sensitive association and dissociation between the N- and C-terminal domains appears to facilitate its localization to the cell membrane |
| Tissue Location | Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. [Isoform v2]: Expressed in microvascular endothelial cells (at protein level) (PubMed:17275676). Expressed in testis (PubMed:11483596). Expressed in endothelial cells and pulmonary artery smooth muscle cells (PubMed:17275676, PubMed:22427510) [Isoform v4]: Expressed in endothelial cells and pulmonary artery smooth muscle cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.
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