|Other Names||Phosphopantothenoylcysteine decarboxylase, PPC-DC, CoaC, PPCDC, COAC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13975a was selected from the N-term region of PPCDC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine.|
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Provided below are standard protocols that you may find useful for product applications.
Biosynthesis of coenzyme A (CoA) from pantothenic acid(vitamin B5) is an essential universal pathway in prokaryotes andeukaryotes. PPCDC (EC 220.127.116.11), one of the last enzymes in thispathway, converts phosphopantothenoylcysteine to4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed11923312]).
Strauss, E., et al. Biochemistry 43(49):15520-15533(2004)Manoj, N., et al. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 10), 1762-1766 (2003) :Daugherty, M., et al. J. Biol. Chem. 277(24):21431-21439(2002)
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