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LRRC8B Antibody (N-term ) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6P9F7 |
|---|---|
| Clone Names | 100416034 |
| Gene ID | 23507 |
|---|---|
| Other Names | Volume-regulated anion channel subunit LRRC8B, Leucine-rich repeat-containing protein 8B, T-cell activation leucine repeat-rich protein, TA-LRRP, LRRC8B, KIAA0231 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13978a was selected from the N-term region of LRRC8B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LRRC8B {ECO:0000303|PubMed:22532330, ECO:0000312|HGNC:HGNC:30692} |
|---|---|
| Function | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The exact function of LRRC8B remains unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Kubota, K., et al. FEBS Lett. 564 (1-2), 147-152 (2004) :Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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