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FCGR2B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P31994 |
|---|---|
| Clone Names | 100427132 |
| Gene ID | 2213 |
|---|---|
| Other Names | Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13987b was selected from the C-term region of FCGR2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FCGR2B |
|---|---|
| Synonyms | CD32, FCG2, IGFR2 |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a low affinityreceptor for the Fc region of immunoglobulin gamma complexes. Theencoded protein is involved in the phagocytosis of immune complexesand in the regulation of antibody production by B-cells. Variationsin this gene may increase susceptibilty to systemic lupuserythematosus (SLE). Several transcript variants encoding differentisoforms have been found for this gene.
References
Prokopec, K.E., et al. Clin. Immunol. 137(3):322-329(2010)Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010)Niederer, H.A., et al. Hum. Mol. Genet. 19(16):3282-3294(2010)Guilabert, A., et al. J. Am. Acad. Dermatol. 63(1):161-163(2010)
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