|Other Names||Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13987b was selected from the C-term region of FCGR2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD32, FCG2, IGFR2|
|Function||Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a low affinityreceptor for the Fc region of immunoglobulin gamma complexes. Theencoded protein is involved in the phagocytosis of immune complexesand in the regulation of antibody production by B-cells. Variationsin this gene may increase susceptibilty to systemic lupuserythematosus (SLE). Several transcript variants encoding differentisoforms have been found for this gene.
Prokopec, K.E., et al. Clin. Immunol. 137(3):322-329(2010)Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010)Niederer, H.A., et al. Hum. Mol. Genet. 19(16):3282-3294(2010)Guilabert, A., et al. J. Am. Acad. Dermatol. 63(1):161-163(2010)
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