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HTRA3 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P83110
Clone Names 100427186
Peptide ID 100427186
Additional Information
Gene ID 94031
Other Names Serine protease HTRA3, 3421-, High-temperature requirement factor A3, Pregnancy-related serine protease, HTRA3, PRSP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13989c was selected from the Center region of HTRA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA3
Synonyms PRSP
Function Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Cellular Location Secreted. Note=Secretion increased during decidualization of endometrial stromal cells
Tissue Location Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney.
Research Areas
Citations (0)

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HTRA3 is probable serine protease.


Zurawa-Janicka, D., et al. Expert Opin. Ther. Targets 14(7):665-679(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Beleford, D., et al. J. Biol. Chem. 285(16):12011-12027(2010)Theoleyre, S., et al. Biochem. Biophys. Res. Commun. 394(3):453-458(2010)Beleford, D., et al. Clin. Cancer Res. 16(2):398-409(2010)

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$ 80.00
Cat# BP13989c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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