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TCF3 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P15923
Clone Names 100427198
Peptide ID 100427198
Additional Information
Gene ID 6929
Other Names Transcription factor E2-alpha, Class B basic helix-loop-helix protein 21, bHLHb21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, Transcription factor 3, TCF-3, Transcription factor ITF-1, TCF3, BHLHB21, E2A, ITF1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13991b was selected from the C-term region of TCF3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCF3
Synonyms BHLHB21, E2A, ITF1
Function Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The TCF3 gene, also called E2A, encodes 2 basichelix-loop-helix (bHLH) transcription factors, E12 and E47, throughalternative splicing. E12 and E47 are involved in regulation ofimmunoglobulin gene expression (Bain et al., 1994 [PubMed8001125]).


Hirose, K., et al. Blood 116(6):962-970(2010)Pan, F., et al. Immunogenetics 62(4):237-251(2010)Hauser, J., et al. Mol. Immunol. 47(5):1031-1038(2010)Rittie, L., et al. Aging Cell 8(6):738-751(2009)Pedraza, N., et al. J. Biol. Chem. 284(47):32980-32988(2009)

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$ 80.00
Cat# BP13991b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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