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PDCD4 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q53EL6
Clone Names 100427289
Additional Information
Gene ID 27250
Other Names Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, PDCD4, H731
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14001c was selected from the Center region of PDCD4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCD4
Synonyms H731
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133)
Tissue Location Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Research Areas
Citations (0)
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Background

This gene encodes a protein localized to the nucleus inproliferating cells. Expression of this gene is modulated bycytokines in natural killer and T cells. The gene product isthought to play a role in apoptosis but the specific role has notyet been determined. Two transcripts encoding different isoformshave been identified.

References

Hayashi, A., et al. Hum. Pathol. 41(11):1507-1515(2010)Zhang, X., et al. Cancer Sci. 101(10):2163-2170(2010)Wang, W., et al. Exp. Cell Res. 316(15):2456-2464(2010)Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)Fassan, M., et al. Oncol. Rep. 24(1):135-139(2010)

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$ 277.78
Cat# BP14001c
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