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PDE11A Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9HCR9
Clone Names 100427306
Peptide ID 100427306
Additional Information
Gene ID 50940
Other Names Dual 3', 5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A, PDE11A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14002a was selected from the N-term region of PDE11A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE11A
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively.
Cellular Location Cytoplasm, cytosol
Tissue Location Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis Isoform 4 is expressed in adrenal cortex
Research Areas
Citations (0)

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The 3',5'-cyclic nucleotides cAMP and cGMP function assecond messengers in a wide variety of signal transductionpathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)catalyze the hydrolysis of cAMP and cGMP to the corresponding5'-monophosphates and provide a mechanism to downregulate cAMP andcGMP signaling. This gene encodes a member of the PDE proteinsuperfamily. Mutations in this gene are a cause of Cushing diseaseand adrenocortical hyperplasia. Multiple transcript variantsencoding different isoforms have been found for this gene.


DeWan, A.T., et al. J. Allergy Clin. Immunol. 126(4):871-873(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :

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$ 80.00
Cat# BP14002a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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