|Other Names||Dual 3', 5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A, PDE11A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14002a was selected from the N-term region of PDE11A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis Isoform 4 is expressed in adrenal cortex|
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Provided below are standard protocols that you may find useful for product applications.
The 3',5'-cyclic nucleotides cAMP and cGMP function assecond messengers in a wide variety of signal transductionpathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)catalyze the hydrolysis of cAMP and cGMP to the corresponding5'-monophosphates and provide a mechanism to downregulate cAMP andcGMP signaling. This gene encodes a member of the PDE proteinsuperfamily. Mutations in this gene are a cause of Cushing diseaseand adrenocortical hyperplasia. Multiple transcript variantsencoding different isoforms have been found for this gene.
DeWan, A.T., et al. J. Allergy Clin. Immunol. 126(4):871-873(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :
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