|Other Names||Chymotrypsin-like elastase family member 2A, Elastase-2A, CELA2A, ELA2A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14005b was selected from the C-term region of CELA2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts upon elastin.|
|Tissue Location||Pancreas. Not detected in keratinocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Elastases form a subfamily of serine proteases thathydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteinselastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the humanelastases, elastase 2A is secreted from the pancreas as a zymogen.In other species, elastase 2A has been shown to preferentiallycleave proteins after leucine, methionine, and phenylalanineresidues.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Lausen, J., et al. Oncogene 25(9):1349-1357(2006)Szepessy, E., et al. Pancreatology 6 (1-2), 117-122 (2006) :
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