|Other Names||Neuronal acetylcholine receptor subunit alpha-5, CHRNA5, NACHRA5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14006c was selected from the Center region of CHRNA5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a nicotinicacetylcholine receptor subunit and a member of a superfamily ofligand-gated ion channels that mediate fast signal transmission atsynapses. These receptors are thought to be heteropentamerscomposed of separate but similar subunits. Defects in this genehave been linked to susceptibility to lung cancer type 2 (LNCR2).
Wessel, J., et al. Neuropsychopharmacology 35(12):2392-2402(2010)Erlich, P.M., et al. Hum. Genet. 128(5):491-499(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Falvella, F.S., et al. J. Natl. Cancer Inst. 102(17):1366-1370(2010)Li, M.D., et al. PLoS ONE 5 (8), E12183 (2010) :
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