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HNRNPM Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P52272 |
|---|---|
| Clone Names | 100430136 |
| Gene ID | 4670 |
|---|---|
| Other Names | Heterogeneous nuclear ribonucleoprotein M, hnRNP M, HNRNPM, HNRPM, NAGR1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14009a was selected from the N-term region of HNRNPM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HNRNPM |
|---|---|
| Synonyms | HNRPM, NAGR1 |
| Function | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| Cellular Location | Nucleus, nucleolus {ECO:0000269|Ref.5}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has threerepeats of quasi-RRM domains that bind to RNAs. This protein alsoconstitutes a monomer of the N-acetylglucosamine-specific receptorwhich is postulated to trigger selective recycling of immatureGlcNAc-bearing thyroglobulin molecules. Multiple alternativelyspliced transcript variants are known for this gene but only twotranscripts has been isolated.
References
Lleres, D., et al. EMBO Rep. 11(6):445-451(2010)Marko, M., et al. Exp. Cell Res. 316(3):390-400(2010)Russo, A., et al. Biochim. Biophys. Acta 1779(12):820-829(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Huang, X., et al. Sci. China, C, Life Sci. 43(6):648-654(2000)
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