|Other Names||Transmembrane protease serine 9, 3421-, Polyserase-I, Polyserine protease 1, Polyserase-1, Serase-1, Serase-2, Serase-3, TMPRSS9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14011a was selected from the N-term region of TMPRSS9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln- Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala- Pro-Ala-AMC are not significantly hydrolyzed.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Okumura, Y., et al. Biochem. J. 400(3):551-561(2006)Cal, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(16):9185-9190(2003)Cal, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(16):9185-9190(2003)
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