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TMPRSS9 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z410 |
|---|---|
| Clone Names | 100430189 |
| Gene ID | 360200 |
|---|---|
| Other Names | Transmembrane protease serine 9, 3421-, Polyserase-I, Polyserine protease 1, Polyserase-1, Serase-1, Serase-2, Serase-3, TMPRSS9 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14011a was selected from the N-term region of TMPRSS9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TMPRSS9 |
|---|---|
| Function | Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Okumura, Y., et al. Biochem. J. 400(3):551-561(2006)Cal, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(16):9185-9190(2003)Cal, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(16):9185-9190(2003)
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