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TLR8 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NR97
Clone Names 100430198
Peptide ID 100430198
Additional Information
Gene ID 51311
Other Names Toll-like receptor 8, CD288, TLR8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14012c was selected from the Center region of TLR8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR8
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theToll-like receptor (TLR) family which plays a fundamental role inpathogen recognition and activation of innate immunity. TLRs arehighly conserved from Drosophila to humans and share structural andfunctional similarities. They recognize pathogen-associatedmolecular patterns (PAMPs) that are expressed on infectious agents,and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibitdifferent patterns of expression. This gene is predominantlyexpressed in lung and peripheral blood leukocytes, and lies inclose proximity to another family member, TLR7, on chromosome X.


Zannetti, C., et al. J. Biol. Chem. 285(45):34773-34780(2010)Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Cros, J., et al. Immunity 33(3):375-386(2010)Enevold, C., et al. Mult. Scler. 16(8):942-949(2010)

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$ 80.00
Cat# BP14012c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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