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NLRP12 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P59046
Clone Names 100430213
Additional Information
Gene ID 91662
Other Names NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14014a was selected from the N-term region of NLRP12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP12
Synonyms NALP12, PYPAF7, RNO
Function Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the RIGI- mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity).
Cellular Location Cytoplasm.
Tissue Location Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Research Areas
Citations (0)
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Background

This gene encodes a member of the CATERPILLER family ofcytoplasmic proteins. The encoded protein, which contains anN-terminal pyrin domain, a NACHT domain, a NACHT-associated domain,and a C-terminus leucine-rich repeat region, functions as anattenuating factor of inflammation by suppressing inflammatoryresponses in activated monocytes. Alternatively spliced transcriptvariants encoding distinct isoforms have been described but thefull-length nature of some of these has not been determined.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Fahy, R.J., et al. Am. J. Respir. Crit. Care Med. 177(9):983-988(2008)Jeru, I., et al. Proc. Natl. Acad. Sci. U.S.A. 105(5):1614-1619(2008)

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$ 277.78
Cat# BP14014a
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