|Other Names||NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14014a was selected from the N-term region of NLRP12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP12, PYPAF7, RNO|
|Function||May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.|
|Tissue Location||Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.|
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This gene encodes a member of the CATERPILLER family ofcytoplasmic proteins. The encoded protein, which contains anN-terminal pyrin domain, a NACHT domain, a NACHT-associated domain,and a C-terminus leucine-rich repeat region, functions as anattenuating factor of inflammation by suppressing inflammatoryresponses in activated monocytes. Alternatively spliced transcriptvariants encoding distinct isoforms have been described but thefull-length nature of some of these has not been determined.
Bailey, S.D., et al. Diabetes Care (2010) In press :Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Fahy, R.J., et al. Am. J. Respir. Crit. Care Med. 177(9):983-988(2008)Jeru, I., et al. Proc. Natl. Acad. Sci. U.S.A. 105(5):1614-1619(2008)
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