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PEX26 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7Z412
Clone Names 100324067
Additional Information
Gene ID 55670
Other Names Peroxisome assembly protein 26, Peroxin-26, PEX26
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14017b was selected from the C-term region of PEX26. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PEX26 {ECO:0000303|PubMed:12717447, ECO:0000312|HGNC:HGNC:22965}
Function Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970).
Cellular Location Peroxisome membrane; Single-pass type II membrane protein
Tissue Location Widely expressed (PubMed:12851857). Highly expressed in kidney, liver, brain and skeletal muscles (PubMed:12851857). Expressed at intermediate level in pancreas, placenta and heart (PubMed:12851857). Weakly expressed in lung (PubMed:12851857).
Research Areas
Citations (0)
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Background

This gene belongs to the peroxin-26 gene family. It isprobably required for protein import into peroxisomes. It anchorsPEX1 and PEX6 to peroxisome membranes, possibly to form heteromericAAA ATPase complexes required for the import of proteins intoperoxisomes. Defects in this gene are the cause of peroxisomebiogenesis disorder complementation group 8 (PBD-CG8). PBD refersto a group of peroxisomal disorders arising from a failure ofprotein import into the peroxisomal membrane or matrix. The PBDgroup is comprised of four disorders: Zellweger syndrome (ZWS),neonatal adrenoleukodystrophy (NALD), infantile Refsum disease(IRD), and classical rhizomelic chondrodysplasia punctata (RCDP).Alternatively spliced transcript variants have been identified forthis gene.

References

Yik, W.Y., et al. Hum. Mutat. 30 (3), E467-E480 (2009) :Tamura, S., et al. J. Biol. Chem. 281(38):27693-27704(2006)Halbach, A., et al. J. Cell. Sci. 119 (PT 12), 2508-2517 (2006) :Furuki, S., et al. J. Biol. Chem. 281(3):1317-1323(2006)Weller, S., et al. Am. J. Hum. Genet. 76(6):987-1007(2005)

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$ 277.78
Cat# BP14017b
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