PITX2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99697 |
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Clone Names | 100430227 |
Gene ID | 5308 |
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Other Names | Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14021a was selected from the N-term region of PITX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PITX2 (HGNC:9005) |
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Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. |
Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:P97474} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the RIEG/PITX homeoboxfamily, which is in the bicoid class of homeodomain proteins. Theencoded protein acts as a transcription factor and regulatesprocollagen lysyl hydroxylase gene expression. This protein plays arole in the terminal differentiation of somatotroph and lactotrophcell phenotypes, is involved in the development of the eye, toothand abdominal organs, and acts as a transcriptional regulatorinvolved in basal and hormone-regulated activity of prolactin.Mutations in this gene are associated with Axenfeld-Riegersyndrome, iridogoniodysgenesis syndrome, and sporadic cases ofPeters anomaly. A similar protein in other vertebrates is involvedin the determination of left-right asymmetry during development.Alternatively spliced transcript variants encoding distinctisoforms have been described.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Banez, L.L., et al. J. Urol. 184(1):149-156(2010)Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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