|Other Names||Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14021a was selected from the N-term region of PITX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARP1, RGS, RIEG, RIEG1|
|Function||Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity).|
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This gene encodes a member of the RIEG/PITX homeoboxfamily, which is in the bicoid class of homeodomain proteins. Theencoded protein acts as a transcription factor and regulatesprocollagen lysyl hydroxylase gene expression. This protein plays arole in the terminal differentiation of somatotroph and lactotrophcell phenotypes, is involved in the development of the eye, toothand abdominal organs, and acts as a transcriptional regulatorinvolved in basal and hormone-regulated activity of prolactin.Mutations in this gene are associated with Axenfeld-Riegersyndrome, iridogoniodysgenesis syndrome, and sporadic cases ofPeters anomaly. A similar protein in other vertebrates is involvedin the determination of left-right asymmetry during development.Alternatively spliced transcript variants encoding distinctisoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Banez, L.L., et al. J. Urol. 184(1):149-156(2010)Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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