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SIRT6 Antibody (C-term) Blocking PeptidesSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP14024b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
SIRT6 Antibody (C-term) Blocking Peptides - Product info | |
| Primary Accession | Q8N6T7 |
| Clone Names | 100430236 |
| Calculated MW | 39119 Da |
SIRT6 Antibody (C-term) Blocking Peptides - Additional info | |
| Gene ID 51548 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP14024b was selected from the C-term region of SIRT6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
SIRT6 Antibody (C-term) Blocking Peptides - Protein Information | |
| Name SIRT6 | |
| Synonyms SIR2L6 | |
| Function NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate | |
| Cellular Location Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions | |
SIRT6 Antibody (C-term) Blocking Peptides - Related products
SIRT6 Antibody (C-term) Blocking Peptides - Research Areas
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BACKGROUND
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).
