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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   NOX4 Antibody (N-term) Blocking peptide   

NOX4 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NPH5
Clone Names 100430266
Peptide ID 100430266
Additional Information
Gene ID 50507
Other Names NADPH oxidase 4, 163-, Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, NOX4, RENOX
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14025a was selected from the N-term region of NOX4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOX4
Synonyms RENOX
Function Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus
Tissue Location Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells
Research Areas
Citations (0)

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This gene encodes a member of the NOX-family of enzymesthat functions as the catalytic subunit the NADPH oxidase complex.The encoded protein is localized to non-phagocytic cells where itacts as an oxygen sensor and catalyzes the reduction of molecularoxygen to various reactive oxygen species (ROS). The ROS generatedby this protein have been implicated in numerous biologicalfunctions including signal transduction, cell differentiation andtumor cell growth. A pseudogene has been identified on the otherarm of chromosome 11. Alternative splicing results in multipletranscript variants.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Salmeen, A., et al. Oncogene 29(31):4473-4484(2010)Wu, R.F., et al. Mol. Cell. Biol. 30(14):3553-3568(2010)Diebold, I., et al. Mol. Biol. Cell 21(12):2087-2096(2010)Manea, A., et al. Biochem. Biophys. Res. Commun. 396(4):901-907(2010)

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$ 80.00
Cat# BP14025a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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