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MCM3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P25205
Clone Names 100430268
Peptide ID 100430268
Additional Information
Gene ID 4172
Other Names DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14026a was selected from the N-term region of MCM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM3
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areinvolved in the initiation of eukaryotic genome replication. Thehexameric protein complex formed by MCM proteins is a key componentof the pre-replication complex (pre_RC) and may be involved in theformation of replication forks and in the recruitment of other DNAreplication related proteins. This protein is a subunit of theprotein complex that consists of MCM2-7. It has been shown tointeract directly with MCM5/CDC46. This protein also interactswith, and thus is acetlyated by MCM3AP, a chromatin-associatedacetyltransferase. The acetylation of this protein inhibits theinitiation of DNA replication and cell cycle progression. [providedby RefSeq].


Lau, K.M., et al. Oncogene 29(40):5475-5489(2010)Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Lee, Y.S., et al. Exp. Mol. Pathol. 88(1):138-142(2010)Song, Y.J., et al. Acta Virol. 54(2):125-130(2010)Saade, E., et al. Proteomics 9(21):4934-4943(2009)

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$ 80.00
Cat# BP14026a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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