ODC1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P11926 |
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Clone Names | 100430279 |
Gene ID | 4953 |
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Other Names | Ornithine decarboxylase, ODC, ODC1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14027b was selected from the C-term region of ODC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ODC1 |
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Function | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the rate-limiting enzyme of thepolyamine biosynthesis pathway which catalyzes ornithine toputrescine. The activity level for the enzyme varies in response togrowth-promoting stimuli and exhibits a high turnover rate incomparison to other mammalian proteins. Originally localized toboth chromosomes 2 and 7, the gene encoding this enzyme has beendetermined to be located on 2p25, with a pseudogene located on7q31-qter.
References
Chaturvedi, R., et al. Gastroenterology 139(5):1686-1698(2010)Zell, J.A., et al. J. Natl. Cancer Inst. 102(19):1513-1516(2010)Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)Hughes, D., et al. Colorectal Dis (2010) In press :Grimminger, P.P., et al. Clin Lung Cancer 11(2):114-119(2010)
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