|Other Names||Ornithine decarboxylase, ODC, ODC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14027b was selected from the C-term region of ODC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the rate-limiting enzyme of thepolyamine biosynthesis pathway which catalyzes ornithine toputrescine. The activity level for the enzyme varies in response togrowth-promoting stimuli and exhibits a high turnover rate incomparison to other mammalian proteins. Originally localized toboth chromosomes 2 and 7, the gene encoding this enzyme has beendetermined to be located on 2p25, with a pseudogene located on7q31-qter.
Chaturvedi, R., et al. Gastroenterology 139(5):1686-1698(2010)Zell, J.A., et al. J. Natl. Cancer Inst. 102(19):1513-1516(2010)Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)Hughes, D., et al. Colorectal Dis (2010) In press :Grimminger, P.P., et al. Clin Lung Cancer 11(2):114-119(2010)
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