|Other Names||Radixin, RDX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14028b was selected from the C-term region of RDX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively|
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Radixin is a cytoskeletal protein that may be important inlinking actin to the plasma membrane. It is highly similar insequence to both ezrin and moesin. The radixin gene has beenlocalized by fluorescence in situ hybridization to 11q23. Atruncated version representing a pseudogene (RDXP2) was assigned toXp21.3. Another pseudogene that seemed to lack introns (RDXP1) wasmapped to 11p by Southern and PCR analyses.
Gloerich, M., et al. Mol. Cell. Biol. 30(22):5421-5431(2010)Kramer, B., et al. Eur. J. Immunol. 39(12):3447-3458(2009)Parisiadou, L., et al. J. Neurosci. 29(44):13971-13980(2009)Belkina, N.V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(12):4707-4712(2009)Wolf, C., et al. BMC Med. Genet. 10, 91 (2009) :
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