|Other Names||Hepatitis A virus cellular receptor 1, HAVcr-1, Kidney injury molecule 1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T-cell immunoglobulin mucin receptor 1, TIM, TIM-1, T-cell membrane protein 1, HAVCR1, KIM1, TIM1, TIMD1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14030a was selected from the N-term region of HAVCR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIM1, TIM1, TIMD1|
|Function||May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a membrane receptorfor both human hepatitis A virus (HHAV) and TIMD4. The encodedprotein may be involved in the moderation of asthma and allergicdiseases. The reference genome represents an allele that retains aMTTVP amino acid segment that confers protection against atopy inHHAV seropositive individuals. Three transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)Garcia-Lozano, J.R., et al. Hum. Genet. 128(2):221-229(2010)Wichukchinda, N., et al. AIDS 24(11):1625-1631(2010)Huo, W., et al. Transplant Rev (Orlando) 24(3):143-146(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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