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HAVCR1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96D42 |
|---|---|
| Clone Names | 100430289 |
| Gene ID | 26762 |
|---|---|
| Other Names | Hepatitis A virus cellular receptor 1, HAVcr-1, Kidney injury molecule 1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T-cell immunoglobulin mucin receptor 1, TIM, TIM-1, T-cell membrane protein 1, HAVCR1, KIM1, TIM1, TIMD1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14030a was selected from the N-term region of HAVCR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HAVCR1 |
|---|---|
| Synonyms | KIM1, TIM1, TIMD1 |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P- selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Regulates also expression of various anti- inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed:17471468). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a membrane receptorfor both human hepatitis A virus (HHAV) and TIMD4. The encodedprotein may be involved in the moderation of asthma and allergicdiseases. The reference genome represents an allele that retains aMTTVP amino acid segment that confers protection against atopy inHHAV seropositive individuals. Three transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].
References
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)Garcia-Lozano, J.R., et al. Hum. Genet. 128(2):221-229(2010)Wichukchinda, N., et al. AIDS 24(11):1625-1631(2010)Huo, W., et al. Transplant Rev (Orlando) 24(3):143-146(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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