Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
NPPC Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23582 |
|---|---|
| Clone Names | 100430291 |
| Gene ID | 4880 |
|---|---|
| Other Names | C-type natriuretic peptide, CNP-22, CNP-29, CNP-53, NPPC, CNP2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14031b was selected from the C-term region of NPPC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NPPC |
|---|---|
| Synonyms | CNP2 |
| Function | [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed:1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034). Binds the clearance receptor NPR3 (PubMed:11533490). |
| Cellular Location | Secreted. |
| Tissue Location | [CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Natriuretic peptides comprise a family of 3 structurallyrelated molecules: atrial natriuretic peptide (ANP; MIM 108780),brain natriuretic peptide (BNP; MIM 600295), and C-type natriureticpeptide, CNP, encoded by a gene symbolized NPPC. These peptidespossess potent natriuretic, diuretic, and vasodilating activitiesand are implicated in body fluid homeostasis and blood pressurecontrol.
References
Lippert, S.K., et al. J. Immunol. Methods 362 (1-2), 32-37 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Wang, Y., et al. J. Cardiovasc. Pharmacol. 55(1):62-66(2010)Cammarata, P.R., et al. Mol. Vis. 16, 630-638 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
