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NPPC Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P23582
Clone Names 100430291
Peptide ID 100430291
Additional Information
Gene ID 4880
Other Names C-type natriuretic peptide, CNP-22, CNP-29, CNP-53, NPPC, CNP2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14031b was selected from the C-term region of NPPC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPPC
Synonyms CNP2
Function Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Natriuretic peptides comprise a family of 3 structurallyrelated molecules: atrial natriuretic peptide (ANP; MIM 108780),brain natriuretic peptide (BNP; MIM 600295), and C-type natriureticpeptide, CNP, encoded by a gene symbolized NPPC. These peptidespossess potent natriuretic, diuretic, and vasodilating activitiesand are implicated in body fluid homeostasis and blood pressurecontrol.

References

Lippert, S.K., et al. J. Immunol. Methods 362 (1-2), 32-37 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Wang, Y., et al. J. Cardiovasc. Pharmacol. 55(1):62-66(2010)Cammarata, P.R., et al. Mol. Vis. 16, 630-638 (2010) :

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$ 80.00
Cat# BP14031b
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