|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, PPP2R5C, KIAA0044|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14034b was selected from the C-term region of PPP2R5C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.|
|Cellular Location||Nucleus. Chromosome, centromere.|
|Tissue Location||Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the phosphatase 2Aregulatory subunit B family. Protein phosphatase 2A is one of thefour major Ser/Thr phosphatases, and it is implicated in thenegative control of cell growth and division. It consists of acommon heteromeric core enzyme, which is composed of a catalyticsubunit and a constant regulatory subunit, that associates with avariety of regulatory subunits. The B regulatory subunit mightmodulate substrate selectivity and catalytic activity. This geneencodes a gamma isoform of the regulatory subunit B56 subfamily.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)Lee, T.Y., et al. J. Biol. Chem. 285(28):21567-21580(2010)Shouse, G.P., et al. Oncogene 29(27):3933-3941(2010)Tung, H.Y., et al. FEBS Lett. 401 (2-3), 197-201 (1997) :McCright, B., et al. J. Biol. Chem. 271(36):22081-22089(1996)
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