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USO1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60763 |
|---|---|
| Clone Names | 100430310 |
| Gene ID | 8615 |
|---|---|
| Other Names | General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, TAP, Vesicle-docking protein, USO1, VDP |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14035b was selected from the C-term region of USO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | USO1 |
|---|---|
| Synonyms | VDP |
| Function | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. |
| Cellular Location | Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a peripheral membraneprotein which recycles between the cytosol and the Golgi apparatusduring interphase. It is regulated by phosphorylation:dephosphorylated protein associates with the Golgi membrane anddissociates from the membrane upon phosphorylation. Ras-associatedprotein 1 recruits this protein to coat protein complex II (COPII)vesicles during budding from the endoplasmic reticulum, where itinteracts with a set of COPII vesicle-associated SNAREs to form acis-SNARE complex that promotes targeting to the Golgi apparatus.Transport from the ER to the cis/medial Golgi compartments requiresthe action of this gene product, GM130 and giantin in a sequentialmanner.
References
Striegl, H., et al. PLoS ONE 5 (2), E8991 (2010) :Merk, M., et al. J. Immunol. 182(11):6896-6906(2009)Mukherjee, S., et al. J. Biol. Chem. 284(3):1709-1717(2009)Striegl, H., et al. PLoS ONE 4 (2), E4656 (2009) :Guo, Y., et al. Mol. Biol. Cell 19(7):2830-2843(2008)
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