|Other Names||Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SRIF-2, SSTR1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14037b was selected from the C-term region of SSTR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach|
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Provided below are standard protocols that you may find useful for product applications.
Somatostatin acts at many sites to inhibit the release ofmany hormones and other secretory proteins. The biological effectsof somatostatin are probably mediated by a family of Gprotein-coupled receptors that are expressed in a tissue-specificmanner. The encoded protein is a member of the superfamily ofsomatostatin receptors having seven transmembrane segments, and isexpressed in highest levels in jejunum and stomach. [provided byRefSeq].
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Pisarek, H., et al. Folia Histochem. Cytobiol. 48(1):142-147(2010)Johansson, M., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1644-1650(2009)Casarini, A.P., et al. Pituitary 12(4):297-303(2009)
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