|Other Names||Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75, HCLS1, HS1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14038b was selected from the C-term region of HCLS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.|
|Cellular Location||Membrane; Peripheral membrane protein Cytoplasm. Mitochondrion|
|Tissue Location||Expressed only in tissues and cells of hematopoietic origin|
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Provided below are standard protocols that you may find useful for product applications.
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Muzio, M., et al. Leukemia 21(9):2067-2070(2007)Lim, J., et al. Cell 125(4):801-814(2006)Hao, J.J., et al. J. Biol. Chem. 280(45):37988-37994(2005)Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Brunati, A.M., et al. J. Biol. Chem. 280(22):21029-21035(2005)
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