|Other Names||Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268, TNFRSF13C, BAFFR, BR3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14039a was selected from the N-term region of TNFRSF13C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.|
|Cellular Location||Membrane; Single-pass type III membrane protein|
|Tissue Location||Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
B cell-activating factor (BAFF) enhances B-cell survivalin vitro and is a regulator of the peripheral B-cell population.Overexpression of Baff in mice results in mature B-cell hyperplasiaand symptoms of systemic lupus erythematosus (SLE). Also, some SLEpatients have increased levels of BAFF in serum. Therefore, it hasbeen proposed that abnormally high levels of BAFF may contribute tothe pathogenesis of autoimmune diseases by enhancing the survivalof autoreactive B cells. The protein encoded by this gene is areceptor for BAFF and is a type III transmembrane proteincontaining a single extracellular cysteine-rich domain. It isthought that this receptor is the principal receptor required forBAFF-mediated mature B-cell survival.
Mihalcik, S.A., et al. J. Immunol. 185(2):1045-1054(2010)Parameswaran, R., et al. Cancer Res. 70(11):4346-4356(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yuan, H., et al. DNA Cell Biol. 29(3):133-139(2010)Yuan, H.X., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(2):111-114(2010)
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