|Other Names||GA-binding protein alpha chain, GABP subunit alpha, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60, GABPA, E4TF1A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14040c was selected from the Center region of GABPA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of three GA-binding proteintranscription factor subunits which functions as a DNA-bindingsubunit. Since this subunit shares identity with a subunit encodingthe nuclear respiratory factor 2 gene, it is likely involved inactivation of cytochrome oxidase expression and nuclear control ofmitochondrial function. This subunit also shares identity with asubunit constituting the transcription factor E4TF1, responsiblefor expression of the adenovirus E4 gene. Because of itschromosomal localization and ability to form heterodimers withother polypeptides, this gene may play a role in the Down Syndromephenotype. Two transcript variants encoding the same protein havebeen found for this gene.
Henderson, A.J., et al. Thorax 65(10):897-902(2010)Eynon, N., et al. Physiol. Genomics 41(1):78-81(2010)Levy, S., et al. IUBMB Life 62(3):237-246(2010)Kim, Y.R., et al. J. Pathol. 220(4):446-451(2010)Bruni, F., et al. J. Biol. Chem. 285(6):3939-3948(2010)
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