|Other Names||Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3, GRIA3, GLUR3, GLURC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14041a was selected from the N-term region of GRIA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression.|
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Provided below are standard protocols that you may find useful for product applications.
Glutamate receptors are the predominant excitatoryneurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. These receptorsare heteromeric protein complexes composed of multiple subunits,arranged to form ligand-gated ion channels. The classification ofglutamate receptors is based on their activation by differentpharmacologic agonists. The subunit encoded by this gene belongs toa family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate)-sensitive glutamate receptors, and is subject to RNAediting (AGA->GGA; R->G). Alternative splicing at this locusresults in different isoforms, which may vary in their signaltransduction properties.
Ripka, S., et al. Neoplasia 12(8):659-667(2010)Liu, Q., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(4):376-378(2010)Feyissa, A.M., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(2):279-283(2010)Marek, G.J., et al. Mol. Pharmacol. 77(3):317-326(2010)Formicola, D., et al. BMC Med. Genet. 11, 103 (2010) :
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