|Other Names||Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14042c was selected from the Center region of STAM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).|
|Cellular Location||Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is closely related toSTAM, an adaptor protein involved in the downstream signaling ofcytokine receptors, both of which contain a SH3 domain and theimmunoreceptor tyrosine-based activation motif (ITAM). Similar toSTAM, this protein acts downstream of JAK kinases, and isphosphorylated in response to cytokine stimulation. This proteinand STAM thus are thought to exhibit compensatory effects on thesignaling pathway downstream of JAK kinases upon cytokinestimulation.
Stuible, M., et al. J. Biol. Chem. 285(31):23899-23907(2010)Rismanchi, N., et al. Traffic 10(2):201-217(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Kong, C., et al. J. Biol. Chem. 282(20):15294-15301(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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