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STAM2 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O75886
Clone Names 100430329
Peptide ID 100430329
Additional Information
Gene ID 10254
Other Names Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14042c was selected from the Center region of STAM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAM2
Synonyms HBP
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Cellular Location Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The protein encoded by this gene is closely related toSTAM, an adaptor protein involved in the downstream signaling ofcytokine receptors, both of which contain a SH3 domain and theimmunoreceptor tyrosine-based activation motif (ITAM). Similar toSTAM, this protein acts downstream of JAK kinases, and isphosphorylated in response to cytokine stimulation. This proteinand STAM thus are thought to exhibit compensatory effects on thesignaling pathway downstream of JAK kinases upon cytokinestimulation.


Stuible, M., et al. J. Biol. Chem. 285(31):23899-23907(2010)Rismanchi, N., et al. Traffic 10(2):201-217(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Kong, C., et al. J. Biol. Chem. 282(20):15294-15301(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP14042c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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