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KIF2C Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99661
Clone Names 100430331
Peptide ID 100430331
Additional Information
Gene ID 11004
Other Names Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK, KIF2C, KNSL6
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14043a was selected from the N-term region of KIF2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF2C
Synonyms KNSL6
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
Cellular Location Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2.
Tissue Location Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Research Areas
Citations (0)

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The protein encoded by this gene is a member ofkinesin-like protein family. Proteins of this family aremicrotubule-dependent molecular motors that transport organelleswithin cells and move chromosomes during cell division. Thisprotein is important for anaphase chromosome segregation and may berequired to coordinate the onset of sister centromere separation.


Tanno, Y., et al. Genes Dev. 24(19):2169-2179(2010)Gnjatic, S., et al. Int. J. Cancer 127(2):381-393(2010)Sanhaji, M., et al. Mol. Cell. Biol. 30(11):2594-2607(2010)Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Kollu, S., et al. Curr. Biol. 19(24):2108-2113(2009)

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$ 80.00
Cat# BP14043a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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