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KIF2C Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99661 |
|---|---|
| Clone Names | 100430331 |
| Gene ID | 11004 |
|---|---|
| Other Names | Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK, KIF2C, KNSL6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14043a was selected from the N-term region of KIF2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KIF2C |
|---|---|
| Synonyms | KNSL6 |
| Function | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end- on conversion of the chromosome-microtubule attachment (PubMed:23891108). |
| Cellular Location | Cytoplasm, cytoskeleton. Nucleus {ECO:0000250|UniProtKB:P70096} Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. {ECO:0000250|UniProtKB:P70096, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:21820309} |
| Tissue Location | Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis- specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member ofkinesin-like protein family. Proteins of this family aremicrotubule-dependent molecular motors that transport organelleswithin cells and move chromosomes during cell division. Thisprotein is important for anaphase chromosome segregation and may berequired to coordinate the onset of sister centromere separation.
References
Tanno, Y., et al. Genes Dev. 24(19):2169-2179(2010)Gnjatic, S., et al. Int. J. Cancer 127(2):381-393(2010)Sanhaji, M., et al. Mol. Cell. Biol. 30(11):2594-2607(2010)Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Kollu, S., et al. Curr. Biol. 19(24):2108-2113(2009)
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